For many people living with Type 2 diabetes, metformin is one of the first medications prescribed to help manage blood sugar levels. It’s well-established, effective, and considered a cornerstone in diabetes care — but like all medications, it can come with side effects that are important to understand, especially when it comes to your skin.
What Is Metformin?
Metformin belongs to a group of medications called biguanides, which help your body use insulin more efficiently. Rather than boosting insulin production, it improves the way your body responds to insulin — making it particularly effective for people with insulin resistance.
It works in three main ways:
- Reduces glucose production in the liver, preventing excess sugar from entering your bloodstream.
- Improves insulin sensitivity in your muscles, helping your body use sugar for energy more effectively.
- Slows glucose absorption from the food you eat.
The result? More stable blood sugar levels and a reduced risk of long-term diabetes complications, from nerve damage to cardiovascular disease.
Common Side Effects of Metformin
Metformin is generally well-tolerated, but some people experience side effects — particularly during the first few weeks of treatment.
Common side effects include:
- Digestive upset — nausea, bloating, or loose stools.
- Abdominal discomfort or a metallic taste in the mouth.
- Loss of appetite or mild weight loss.
Tip: Taking metformin with meals or using an extended-release version can help reduce stomach irritation.
Less Common but Serious Side Effects
While rare, more serious side effects can occur and should be discussed with your healthcare provider:
Lactic acidosis: A rare buildup of lactic acid in the blood, leading to fatigue, muscle pain, or difficulty breathing. Seek medical help immediately if these symptoms appear.
Vitamin B12 deficiency: Long-term use of metformin may lower vitamin B12 levels, which can cause fatigue, weakness, or tingling in the hands and feet. Regular blood tests and supplements can help prevent this.
Metformin and Your Skin
Many people don’t realise that diabetes and its medications can also influence skin health.
Some individuals taking metformin notice:
- Increased dryness or sensitivity, especially if vitamin B12 levels drop.
- Delayed healing of small cuts or irritations due to lower blood flow or reduced nerve sensitivity.
- Fluctuations in oil production — in some cases, metformin may help balance oil levels and reduce acne, while others may notice the opposite.
When taking metformin, your skin may need a little extra support. A gentle, protective routine can make a visible difference in comfort and resilience.
Try:
- Barrier+ Cream;— to deeply hydrate and strengthen the skin barrier.
- Foot Shield;— to protect vulnerable areas prone to dryness and cracking.
- Hydrate+ Serum;— to replenish moisture and keep skin supple throughout the day.
Our range is specifically developed for diabetic skin, with dermatologist-tested, non-irritating formulas that work in harmony with your medication and daily care routine.
The Bottom Line
Metformin remains one of the most effective and trusted medications for Type 2 diabetes. Most side effects are mild and temporary, and the benefits for blood sugar control far outweigh the risks.
However, if you notice changes in your skin or overall comfort, don’t ignore them — talk to your doctor and ensure your skincare routine supports your body’s changing needs.
Your skin is an important part of your health journey.
At The Diabetic Skin Care Company, we’re here to help you protect it — every step of the way.
